Cisplatin p53

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August undefined, 2024

Webω-3 PUFAs regulated p53-mediated apoptosis, leading to protection of BM cells from apoptosis/cell cycle arrest induced by cisplatin. • ω-3 PUFAs inhibited cisplatin-induced oxidative damage in BM cells via activation of the NRF2-MDM2 pathway. Abstract Cisplatin is a chemotherapy medication used to treat a wide range of cancers. WebMay 26, 1998 · Cisplatin treatment of teratocarcinoma cells with a wild-type p53 gene resulted in accumulation of the p53 protein through posttranscriptional mechanisms; induction of p53-target genes was also observed. Drug treatment resulted in rapid apoptosis in p53-wild-type cells but not in p53 −/− teratocarcinoma cells.

Cisplatin-Induced Renal Injury Is Independently Mediated by OCT2 and p53

WebIC50 values indicated less toxicity of the Schiff base complex on GMSCs compared to cisplatin. Schiff base complex treatment resulted in up-regulation of p53 and Bax genes … how many days til 3rs of march

Anti-Tumor Effects of Wee1 Kinase Inhibitor with Radiotherapy in …

WebFeb 28, 2024 · The p53 signaling pathway is involved in cisplatin-induced acute kidney injury (AKI). Western blot analysis showed that p53 was activated in the kidney ( Figures … WebOct 9, 2024 · However, the cisplatin resistance of cells associated with p53 and RAS status was quite different because the inhibition of STAT3 without regard of RAS V12 reduced the IC50 of cells to cispaltin ... WebJan 30, 2024 · (D) Mechanism that CKI sensitizes p53-mutant CRC cells to cisplatin. The R273H/P309S mutation of p53 rendered CRC cells insensitive to Cis and 5FU treatments. The in vitro anti-CRC profiles of CKI + Cis combination were distinct from that of CKI+5FU. CKI decreased drug sensitivity to 5FU in both p53 wild and R273H/P309S mutation CRC … high standard 22 mag derringer reviews

Apoptosis by cisplatin requires p53 mediated p38α MAPK …

Frontiers PRIMA-1 inhibits Y220C p53 amyloid aggregation and ...

WebMay 26, 1998 · The p53-mutant mouse teratocarcinoma cells did not undergo cisplatin-induced apoptosis, although clonogenic assays revealed an overall sensitivity similar to … WebThe average ID (50) (drug dose required to inhibit 50% of cell growth) for cell lines with mutant p53 was 6.8 microM, whereas the average ID (50) for cell lines with wild-type p53 … high standard 22 calWebJul 19, 2024 · Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors to cisplatin (CDDP) resistance. Substantial evidence suggests the elevated levels of reactive oxygen species … high standard 20 gauge pump shotgun

"WebMay 26, 2006 · In the p53- and MMR-proficient cells, cisplatin induced a 17-fold increase in homologous recombination even when the recombining sequences that did not contain cisplatin adducts; the magnitude of induction was even greater in cells that had lost either one or both functions. " - Cisplatin p53

Cisplatin p53

Frontiers PRIMA-1 inhibits Y220C p53 amyloid aggregation and ...

WebDuring cisplatin treatment, p53 was activated. The inhibition of p53 by pifithrin-α attenuated the cisplatin-induced kidney injury and up-regulated miR-142-5p expression. We also identified the Sirtuin7 (SIRT7) as a target of miR-142-5p. WebWe also demonstrate that the combination of PRIMA-1 and cisplatin is a promising approach for HCC therapy. Taken together, our data support the premise that targeting the amyloid-state of mutant p53 may be an attractive therapeutic approach for HCC, and highlight PRIMA-1 as a new candidate for combination therapy with cisplatin.

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Webp53 mediates cisplatin-induced apoptosis in renal proximal tubular cells, and p53 can activate caspase-3 . Related to this, Li et al. described that HRPTEp cells treated with DDP for 48 h showed that DDP led to significantly upregulated miR-449a. In the same way, the overexpression of miR-449a led to an increased apoptotic rate of HRPTEpCs ... WebApr 11, 2024 · 2024年查处的不端行为案件处理结果通报（第一批次）. 近期，经国家自然科学基金委员会监督委员会调查审议、国家自然科学基金委员会委务会议审定，国家自然科学基金委员会对相关科研不端案件涉事主体进行了处理。. 现将给予通报批评的有关案情及处理 ...

WebOct 28, 2024 · The mutational status of p53 seems to be related to the preferential response of tumor cells to Wee1 inhibitors 21 – 23. Studies have shown that AZD1775 radiosensitized p53-defective human cells derived from lung, breast, and prostate cancers by abrogating the radiation-induced G2 block, while this was not observed in p53 wild-type cells 24 ... WebFeb 13, 2024 · Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz that has been shown to …

WebSep 6, 2024 · Cisplatin treatment increased p53 phosphorylation and decreased E-cadherin expression. Administration of MM102 reversed these changes. These data suggest that protection against AKI conferred... WebThe inhibition of p53 by pifithrin-α attenuated the cisplatin-induced kidney injury and up-regulated miR-142-5p expression. We also identified the Sirtuin7 (SIRT7) as a target of miR-142-5p.

WebCisplatin inhibited glycolysis via p53 activation. (A) Western blot analysis indicated increased levels of p53 and phospho-p53 after 6 and 24 h of cisplatin treatment. The …

WebFeb 10, 2024 · Cisplatin, a broad-spectrum anti-tumor chemotherapeutic agent, is used in clinical practice for the treatment of various types of tumors 1, including hepatocellular carcinoma (HCC) and cervical... high standard 22WebActivation and involvement of p53 in cisplatin-induced nephrotoxicity. Cisplatin, a widely used chemotherapy drug, induces acute kidney injury, which limits its use and efficacy in … National Center for Biotechnology Information how many days til christmasWebMay 16, 2007 · Cisplatin induces p53 mitochondrial translocation: Effect of pifithrin-α. HCT116 wt cells (pre-treated or not with 10 μM pifithrin-α for 16 h) were treated with 50 μM cisplatin for 30 min or maintained untreated. Then, mitochondrial and cytosolic ( A) or total cell extracts ( B) were obtained. how many days til christmas 2031WebMay 7, 2024 · Consistently, genetic depletion or pharmacological inhibition of USP10 dramatically reduces the growth of lung cancer xenografts lacking wild-type p53 and sensitizes them to cisplatin.... how many days til dec 16 2022WebDec 14, 2024 · Sensory neurotoxicity is a major, dose-limiting side effect of cisplatin, and recovery from CDDP-induced neuropathy is often incomplete; persisting in up to 55% of patients, even years after the... how many days til christmas 2022 australiaWebWe also demonstrate that the combination of PRIMA-1 and cisplatin is a promising approach for HCC therapy. Taken together, our data support the premise that targeting … high standard 22 magnumWebJan 1, 2024 · The p53 and p21 proteins, which are senescence modulators, were upregulated at 48 h after cisplatin treatment ( Fig. 1 E and F). The mRNA levels of senescence-associated secretory phenotype (SASP) factors including interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α were increased in NRK cells at 48 h after … high standard 22 for sale