WebJan 7, 2013 · Furthermore, the BNF considers only simvastatin—not atorvastatin—to have a “potentially serious” interaction with grapefruit juice. The key literature regarding simvastatin is as follows. In a Finnish study 3, healthy volunteers consumed multiple daily doses of double-strength GFJ prior to and on the day of taking a first dose of 60mg ... WebApr 17, 2024 · That study, which also includes pomegranates and celery on the list of foods with furanocoumarin, concluded that moderate amounts of grapefruit won't interfere significantly with statins. Importantly, …
Zocor and Alcohol/Food Interactions - Drugs.com
WebHere are examples of some types of drugs that grapefruit juice can cause problems (interact) with: • Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin). • Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine). ... WebNov 1, 1998 · The effect of grapefruit juice on the pharmacokinetics of atorvastatin and pravastatin is studied and it is shown that grapefruit Juice greatly increases the bioavailability of lovastsatin and simvastsatin. 239 Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin J. Lilja, K. Kivistö, P. Neuvonen ravi bishnoi catch
The Grapefruit-Drug Interaction Debate: Role of Statins AAFP
WebAug 25, 2024 · On the other hand, higher statin levels can also boost their cholesterol-lowering effects. For example, one study found that there were improvements in LDL … WebGrapefruit juice was administered with breakfast for 3 days, and simvastatin was administered in the evening on Day 3. Coadministered Drug or Grapefruit Juice: Dosing of Coadministered Drug or Grapefruit Juice: Dosing of Simvastatin: Geometric Mean Ratio (Ratio * with / without coadministered drug) No Effect = 1.00: AUC WebFeb 10, 2024 · Yes, you should not eat grapefruit or drink grapefruit juice while taking Lipitor (atorvastatin). Compounds in grapefruit can negatively interact with certain … ravichagua