Phenytoin intoxication

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August undefined, 2024

WebJul 11, 2024 · Overdose on oral phenytoin mainly causes neurotoxicity, whereas cardiovascular toxicity is the main side effect of parenteral administration. Neurotoxicity The neurotoxic effects are concentration-dependent and can range from mild nystagmus to ataxia, slurred speech, vomiting, lethargy, and eventually coma and death. WebPhenytoin intoxication is usually benign and symptoms are dose-related. Rapid IV administration may result in cardiac arrhythmias due to the propylene glycol contained in …

Phenytoin Toxicity Clinical Presentation - Medscape

WebJan 1, 2005 · Phenytoin intoxication may present as generalized weakness, headache, nausea, vomiting, abdominal pain, tremor, nystagmus, slurred speech, diplopia, blurred vision, incordination,... WebJan 15, 2024 · Phenytoin toxicity can occur from an increase in the daily dose of phenytoin, changes in the formulations or brands as well as changes in the frequency of … do girls find chest hair attractive

Phenytoin Toxicity Differential Diagnoses - Medscape

WebJan 1, 2005 · Phenytoin is a commonly prescribed antiepileptic drug. Due to its saturation (zero-order) pharmacokinetics, phenytoin carries a special risk of dose-related toxicity … WebJan 15, 2024 · Phenytoin toxicity can occur from an increase in the daily dose of phenytoin, changes in the formulations or brands as well as changes in the frequency of … WebPhenytoin is a medicine used to treat convulsions and seizures. Phenytoin overdose occurs when someone accidentally or intentionally takes too much of this medicine. This is for … do girls find beanies attractive

Phenytoin/sodium-valproate SpringerLink

WebThe CPEHTT intoxication caused by phenytoin toxicity represents a drug safety problem in China. The common clinical manifestations, serum phenytoin concentrations, and … WebSep 4, 2024 · Fosphenytoin is a medication used to manage seizures (treatment of generalized tonic-clonic status epilepticus, focal [partial] onset seizures, or generalized onset seizures, and for the prevention and treatment of seizures occurring during neurosurgery). It is a water-soluble phenytoin prodrug that can be employed in situations where phenytoin ... fahrwerkk educate onlineWebNov 3, 2024 · Phenytoin intoxication can occur either with repeated supra therapeutic dosing or an acute overdose. Dose-dependent CNS depression occurs. Most … do girls find funny guys attractive

"WebJan 15, 2024 · Phenytoin toxicity can occur from an increase in the daily dose of phenytoin, changes in the formulations or brands as well as changes in the frequency of administration. It can also occur when patients are started on new medications that interact with the metabolism or binding capacity of phenytoin to plasma proteins. " - Phenytoin intoxication

Phenytoin intoxication

WebDec 1, 2004 · Causes of acute phenytoin intoxication in 36 episodes Causes of intoxication Frequency Suicide attempt 1 Improved compliance 1 Iatrogenic 4 Misunderstanding of the 5 prescription order Undetermined 5 Probable drug interaction 6 Excessive self-medication 14 (patient-initiated dose increase) Kaohsiung J Med Sci December 2004 • Vol 20 • No 12 … WebJan 26, 2024 · Phenytoin increases serum levels of toxic metabolites of the following: Acetaminophen Oral anticoagulants Primidone (eg, phenobarbital) Phenytoin decreases serum levels of the following:...

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WebSep 15, 2024 · Phenytoin (eg, Dilantin) is an anticonvulsant medication used to treat many seizure disorders. It is also a Vaughan-Williams class IB antiarrhythmic agent, although it is now infrequently used for that indication. Phenytoin toxicity is rarely fatal, but can cause … WebPhenytoin toxicity may result from intentional overdose, dosage adjustments, drug interactions, or alterations in physiology. Intoxication manifests predominantly as nausea, central nervous system dysfunction (particularly confusion, nystagmus, and ataxia), with depressed conscious state, coma, and seizures occurring in more severe cases.

WebDec 1, 2004 · Causes of acute phenytoin intoxication in 36 episodes Causes of intoxication Frequency Suicide attempt 1 Improved compliance 1 Iatrogenic 4 Misunderstanding of … WebJun 25, 2013 · As phenytoin is a known hepatic enzyme inducer, it may affect the metabolism and serum concentrations of thyroid hormones and cause features of hypothyroidism. 3–5 Gastrointestinal abnormalities associated with phenytoin toxicity have not been documented in the literature.

WebFeb 9, 2024 · swollen, painful, or tender lymph glands in the neck, armpit, or groin unusual bleeding or bruising unusual tiredness or weakness upper right abdominal or stomach pain vomiting weight loss yellow eyes or skin Other side effects of Phenytoin Some side effects of phenytoin may occur that usually do not need medical attention. WebJul 16, 2024 · Answer: Phenytoin Toxicity1-6 Therapeutic Indications: Anticonvulsant indicated for the control of generalized tonic-clonic and complex-partial seizures, and for the prevention and treatment of seizures occurring during or after neurosurgery. 1,2 Drug Facts:

Weband low toxicity threshold of phenytoin can often result in its intoxication.2,4,7,8 The toxic effects of chronic use may present with wide variety of clinical symptoms and signs.2 Here we report a case of phenytoin toxicity in an adolescent female presenting with multiple adverse drug reactions (ADRs). CASE REPORT

WebSymptoms of phenytoin toxicity include nystagmus, diplopia, slurred speech, ataxia, confusion, and hyperglycaemia. Allergy and cross-sensitivity For phenytoin Cross … do girls fightingWebNational Center for Biotechnology Information do girls find tall guys attractiveWebNov 29, 2004 · Toxicity is characterized by a continuum of neurologic signs and symptoms: nystagmus, ataxia, drowsiness, dysarthria, hyperreflexia, coma, and respiratory … fahrwerk golf 7 faceliftWebPhenytoin is a commonly prescribed antiepileptic drug. Due to its saturation (zero-order) pharmacokinetics, phenytoin carries a special risk of dose-related toxicity that is an … fahrwerk jeep compassWebJul 11, 2024 · Phenytoin is a Class IB antiarrhythmic; its suppressant effects on the cardiac voltage-gated sodium channels can lead to dysrhythmias as well as sinoatrial and atrioventricular blocks. These effects rarely occur … do girls find strech marks unatractiveWebMay 2, 2024 · Phenytoin is an anti-epileptic drug, also called an anticonvulsant. Phenytoin works by slowing down impulses in the brain that cause seizures. Phenytoin is used to … do girls finishWebApr 1, 2024 · nausea. numbness, tingling, or pain in the hands or feet. painful or difficult urination. pale skin. pinpoint red spots on the skin. red skin lesions, often with a purple center. red, irritated eyes. redness and swelling of the gums. slow or irregular heartbeat. do girls find necks attractive